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What is it?

One capsule of Trivestin� contains:

Trevistat Forte 515 mg, a proprietary blend of:

WHAT DOES IT DO?

Trivestin� affords significant reduction of joint pain and stiffness and is twice as effective as Celebrex�.

According to the manufacturer:

"With joint pain adversely affecting more than 80 million Americans, science continues its search for the �perfect� pain reliever. Materials that have the ability to affect the IL-1 Beta inflammatory compound, the COX-2 inflammatory enzyme, and the 5-LO inflammatory pathway are prime targets. For example, Celebrex,� the most popular prescription anti-inflammatory, has been shown to selectively inhibit the COX-2 enzyme (but not the 5-LO inflammatory pathway). Glucosamine, a dietary supplement widely used in the treatment of joint pain, is neither a selective COX-2 nor a selective 5-LO inhibitor (although it may have other benefits).

Trivestin�, a novel combination of plant extracts, singled out from more than 1,228 carefully screened candidate plants, was selected for its ability to block these established inflammatory enzymes and pathways. Because rigorous laboratory trials confirmed Trivestin�s proficiency in inhibiting gene expression of compounds that cause inflammation, pain, and joint degradation (including IL-1 Beta, COX-2, and 5-LO), it was predicted that Trivestin would not only reduce pain, but also preserve the integrity of joint tissue. To establish Trivestin�s safety and efficacy (and mitigate the subjective nature of pain relief) a clinical trial was designed to compare Trivestin to both placebo and Celebrex, a recognized standard.

METHODS: 30-day, head-to-head, double-blind clinical data were evaluated to compare safety and efficacy of Trivestin to Celebrex. Sixty (60) subjects with confirmed osteoarthritic joint pain were divided equally into four (4) groups: Group 1 � Placebo (sugar pill); Group 2 � Celebrex (200 mg per day); Group 3 � Trivestin (250 mg per day); and Group 4 � Trivestin (500 mg per day). Subjects were instructed to take the prescribed capsules in divided doses twice per day. Improvements in joint pain, mobility, flexibility, stiffness, and ease of motion (�Quality Of Life� parameters) were assessed at 30 days using the standard WOMAC and SF-36 (Short-Form) evaluations.

RESULTS: Trivestin was shown to be twice as effective as Celebrex (Group 3: p<0.06; Group 4: p<0.05) [over and above placebo, of course] in reducing pain and stiffness, increasing mobility and flexibility, and improving overall quality of life.

CONCLUSIONS: The ability of Trivestin to block multiple inflammatory enzymes and pathways (COX-2, IL-1 Beta, and 5-LO) seems to account for Trivestin�s superiority over Celebrex under the conditions of this double-blind, clinical comparative trial. "

The manufacturer has a money back guarantee with this product.

CAUTIONS

Trivestin should not be consumed by subjects with a history of gastric or duodenal ulcer, subjects on H2 blockers, or subjects on proton pump inhibitors.

If you are pregnant or lactating consult your doctor.

See Disclaimer.

DOSE

Take one capsule with a full glass of water 2 or 3 times daily depending upon the severity of the pain. Do not exceed 3 capsules per day. Trivestin may be taken with or without food. If you are taking Celebrex or any prescription anti-inflammatory drug, check with your doctor before taking Trivestin or discontinuing your present medication.

NHC sells 56 capsule boxes of Trivestin for $31.95 $37.68. The suggested retail price is $41.87.

CII

These statements have not been evaluated by the U.S. Food & Drug Administration (FDA).
The products discussed are not intended to diagnose, treat, cure, or prevent any disease.
 

Created  March 1, 1998 (Personal page April 25, 1995)
(This site was created from FrontPage 2000 at a resolution of 1024x768 in 32 bit color on a 19 inch monitor. It was checked using Microsoft IE 5.0. Your results may vary depending upon your browser, monitor, and color resolution.) Updated on May 25, 2003.
Gerry Wolke, RPh.