Dual-Action Cruciferous Vegetable Extract with Resveratrol & Cat's Claw
by Life Extension
WHAT IS IT?
Dual-Action Cruciferous Vegetable Extract with Resveratrol & Cat's Claw contains in each capsule:
| Broccoli (Brassica oleracea l.) Super Concentrate Extract (plant and sprouts) [standardized to 4% glucosinolates (16 mg)] | 400 mg |
| Watercress (Nasturtium officinale) 4:1 Extract (leaf) | 100 mg |
| Indole-3-Carbinol (I3C) | 80 mg |
| Rosemary (Rosmarinus officinalis) Extract (leaves) [standardized to 20% diterpenic compounds (10 mg) and providing carnosic acid/carnosol] | 50 mg |
| DIM (Di-indolyl-methane) | 14 mg |
| Resveratrol [from Red Grape (Vitis vinifera) Extract (whole fruit) and Polygonum cuspidatum Extract (root)] | 20 mg |
Cat's Claw (Uncaria tomentosa) Extract (bark) [std. to 8% carboxy alkyl esters (4 mg)] | 50 mg |
Other ingredients: gelatin, rice flour, magnesium stearate, maltodextrin, titanium dioxide.
WHAT DOES IT DO?
According to the manufacturer:
Reprinted with permission of Life Extension.
"Scientists have identified specific extracts from cruciferous vegetables (broccoli, cauliflower, Brussels sprouts, etc.) that modulate hormones in a way to help maintain healthy cell division. For instance, animal studies have shown that the cruciferous vegetable extract indole-3-carbinol (I3C) modulates estrogen hormones by favorably changing the ratio of protective 2-hydroxyestrone versus the damaging 16-hydroxyestrone.81 Indole-3-carbinol also induces phase I and II detoxifying enzymes that can help neutralize estrogen metabolites and xenobiotic estrogen-like environmental chemicals.82 Human studies support the beneficial role of I3C in positively altering estrogen metabolism.83 Di-indolyl-methane (DIM), a phytonutrient found in cruciferous vegetables, has been shown in animal studies to help maintain normal levels of a potentially damaging estrogen called 4-hydroxyestrone.85
I3C and DIM have been shown to affect the proliferation of cells containing DNA damage and induce DNA repair proteins. The glucosinolates are major constituents of cruciferous vegetables that have been shown to promote normal apoptosis and induce the expression of the beneficial p53 gene via an estrogen-independent action.86
Watercress contains isothiocyanates, but in a broader spectrum than does broccoli. The primary isothiocyanate precursor (PEITC) in watercress functions via four specific mechanisms to maintain healthy cell division.87 Extracts from rosemary enhance liver metabolism of estradiol and estrone,88 and help regulate the formation of DNA adducts,89 and have been shown to impede estrogen-induced growth promotion in certain tissues.88
Life Extension has combined its cruciferous vegetable complex with a standardized resveratrol extract based on indications from published scientific literature that resveratrol may also be an effective plant extract for maintaining optimal health. This organic whole-grape extract contains a spectrum of polyphenols naturally found in red wine, such as proanthocyanidins, anthocyanins, and flavonoids."
CAUTIONS
May interfere with oral contraceptives. If pregnant or intending to become pregnant, do not use this product. Do not use if taking antacids, H2-receptor blockers (e.g. Zantac), or proton-pump inhibitors (e.g. Nexium), as these drugs may impede the conversion of I3C to active metabolites.
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Disclaimer.
DOSE
For those weighing less than 160 pounds, just one capsule a day provides optimal potencies. Those weighing over 160 pounds should consider taking one capsule twice a day. It may be taken with or without food.
NHC sells 60 capsule bottles of Dual-Action Cruciferous Vegetable Extract with Resveratrol for
$24.00. The suggested retail price is $32.00. The manufacturer prohibits further discount of this product.
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