CR Mimetic Longevity Formula
by Life Extension
WHAT IS IT?
Each 2 vegetarian capsules of CR Restriction Longevity Formula contains:
| Trans-Resveratrol [from Polygonum cuspidatum (root) extract] | 250 mg |
| Trans-Pterostilbene (as pure Pterospan and SMART pterostilbene) | 3 mg |
| Quercetin (from quercetin dihydrate) | 150 mg |
| MASQUELIERs Original OPCs [single and condensed (2-5) units of flavanols & polyphenols from Vitis vinifera (grape) seeds] | 50 mg |
| Black tea (Camellia sinensis) extract (leaf) [standardized to 12% TF2a theaflavin fraction (36 mg), along with TF1, TF2b and TF3 theaflavin fractions] | 300 mg |
| Fisetin [from (Rhus succedanea L.) extract (stem)] | 48 mg |
Other ingredients: vegetable cellulose (capsule), stearic acid, silica, vegetable stearate
WHAT DOES IT DO?
According to the manufacturer:
Reprinted with permission of Life Extension.
"In 2003, the Life Extension Foundation introduced a standardized extract of resveratrol, a natural compound shown to favorably alter genes implicated in the aging processmany of the same genes that respond to calorie restriction or CR. In 2009, we introduced pterostilbene, a compound whose effects were found to work in synergy with resveratrol to activate your longevity genes."
This year, we advanced the field even further, bringing together the 5 known calorie restriction mimetics in a single, high potency formula: resveratrol, pterostilbene, quercetin, grape seed polyphenols, and black tea extract.1-8 Now we announce the latest innovation in the science of longevity with new CR Mimetic Longevity Formula featuring fisetin. This little-known flavonoid is the sixth compound shown to simulate a similar youthful gene expression pattern as calorie restriction9without significant dietary modification. In the most exciting development to date, this novel compound (fisetin) may also enhance the effects of resveratrol.10
Life Extension has gone to extraordinary lengths to identify compounds that simulate calorie restrictions ability to trigger youthful gene expressionthe process by which genes transmit signals that slow certain aspects of aging. For example, previous research funded by Life Extension showed that a combination of low-dose (20 mg) resveratrol plus grape seed extract induced many of the favorable gene expression changes observed in calorie-restricted animals. A comprehensive review of the scientific literature further revealed that certain compounds found in berries, such as pterostilbene, also possess potent longevity gene activators that work in synergy with resveratrol.
Most abundant in strawberries, fisetin has the power to switch on powerful cell signaling molecules that support youthful gene expression, DNA protection, and healthy cellular function.9 It also supports aging neurons in the presence of oxidative stress.11-13 Each serving of the new CR Mimetic Longevity Formula contains fisetin in an amount equivalent to 2 cups of strawberries, helping to further emulate calorie restrictions favorable influence on your longevity genes. Most importantly, fisetin works in synergy with resveratrol. Researchers have uncovered compelling evidence of fisetins ability to stabilize resveratrol by shielding it from metabolic breakdown10 and extending its effects.
This new formula provides cutting-edge broad spectrum support for youthful gene expression from the most scientifically validated, natural sources."
CAUTIONS
Use caution if pregnant or nursing. Consult with your doctor before using this product if you have a bleeding disorder, or if you are taking anticoagulant or antiplatelet medications, or diabetic medications.
See
Disclaimer.
DOSE
Take two capsules daily with or without food, or as recommended by a healthcare practitioner. Can be taken together or in a divided dose.
NHC sells 60 vegetarian capsule bottles of for
$29.25. The suggested retail price is $39.00. The manufacturer prohibits further discount of this product.
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